Endocrine Abstracts

Resveratrol (trans-3,4,5-trihydroxystilbene, RES), a phytoestrogen, exists in grape skin and red wine. Endocrine disrupting chemicals (EDCs) appear to promote the development and progression of the estrogen dependant cancers. In this study, we evaluated the inhibitory effect of RES on the cell growth and progression induced by various EDCs in BG-1 ovarian cancer cells expressing estrogen receptors (ERs). The various EDCs, i.e., bisphenol A (BPA), nonylphenol (NP), octylphenol ...

One of estrogens, 17b-estradiol (E2), is a pleiotropic hormone that regulates the growth and differentiation of many tissues and also acts as a mitogen that promotes the development and proliferation of hormone-responsive cancers. Bisphenol A (BPA) is a widely used industrial compound and classified as one of endocrine disrupting chemicals (EDCs) and especially a xenoestrogen that imitates estrogen in living organisms. In this study, we examined the effect of a phytoestrogen, ...